Proteomics at Genotypic Technology

Introduction

The SomaScan Assay from SomaLogic is a proteomic technology for high throughput, simultaneous measurement of high and low-abundant proteins. The SomaScan Platform is a highly multiplexed, sensitive, quantitative, and reproducible proteomic tool for discovering previously unidentified biomarkers for drug discovery, pre-clinical and clinical drug development, and clinical diagnostics, across a wide range of important diseases and conditions.

The SomaScan Platform is enabled by the generation of protein-capture reagents called SOMAmer® (Slow Off-rate Modified Aptamer) reagents. The platform measures native proteins in complex matrices by transforming available binding sites on individual proteins into a corresponding SOMAmer reagent concentration, which is then quantified by hybridization to microarrays. The assay takes advantage of SOMAmer reagents’ dual nature as both protein affinity-binding reagents with defined three-dimensional structures and unique nucleotide sequences recognizable by specific DNA hybridization probes.

The SomaScan Platform is being applied to a wide range of diseases and conditions to deliver insights that enable biomarker discovery, diagnostics development, pharmaceutical discovery and development, and health management.

Feature	7K Assay	11K Assay
Proteins Measured	7,000 total protein measurements including 6,700 unique human proteins measured Sample size: 55 µL	11,000 total protein measurements including 10,000 unique human proteins measured Sample size: 55 µL
Sample Types	Blood, plasma, serum, tissue, cell lysates, etc. Human and non-human plasma and serum	Blood, plasma, serum, tissue, cell lysates, etc. Human and non-human serum and plasma, tissue, cerebrospinal fluid (CSF), urine, and more
Key Features	High throughput, Sensitivity across a wide dynamic range, Reproducibility, Versatility	Expanded coverage of protein targets, Enhanced resolution, Advanced data analysis capabilities
Applications	Biomarker discovery, Drug discovery, Disease mechanisms	Systems biology, Personalized medicine, Translational research

Key features of SomaScan Assay:

High Specificity - designed for specificity utilizing highly validated protein affinity
Highest multiplex – profiles 11k protein measurement including 10k unique human protein measurement
Low sample volume – Perform a single assay run with 55 micro litre of serum or plasma. Other biological sample types can also be performed
Reproducibility – Low CV of ~5% with both 7K and 11K assay
High throughput - ability to scale up sample process very rapidly
Sensitivity dynamic range – 10-log dynamic range from fM to micro Molar
Correlated data – combine data for core samples without the need for bridging data

SomaScan Custom Panels for Targeted Proteomics Insights

A wide range of protein analytes are available for research needs with curated disease-specific panels or customized panels that can be created from the SomaScan 11K Assay menu for various applications in translational sciences listed below:

Target Identification and Validation
Pharmacokinetics and Pharmacodynamics
Enrichment and Stratification for Clinical Trials
Disease Biology Modelling
Disease Sub-Phenotyping
Pathway Regulation Investigation

Choose Disease-Specific Panels:

Inflammation and immune response
Oncology
Neuroscience
Cardiovascular disease
Metabolic diseases
Respiratory
Cytokines

SomaSignal Tests

SomaSignal Tests provide multiple clinical assessments from a single blood draw based on protein signature models, negating the need for a wide range of laboratory tests. Because each SomaSignal Test is generated using a subset of the 7,000 proteins measured by the SomaScan™ Assay, results for all of the SomaSignal Tests can be derived from a single 55 μl blood sample.

Applications

Advantages

Why choose Genotypic?

Quality Assurance: Trust in our commitment to delivering accurate, reliable, and reproducible results, upheld by stringent quality control measures.
Collaboration: Partner with us to accelerate your research and drive innovation in proteomics, supported by our collaborative approach and dedication to scientific excellence.
Impact: Join the global scientific community in advancing knowledge and transforming healthcare through groundbreaking discoveries in proteomics.

Embark on Your Proteomics Journey with Genotypic Technology!

Contact Information: Email: genomics@genotypic.co.in

Phone number: +91-9900035748 (Swapnil – for academics/university), +91 99000 35739 (Bharath – for corporate sector)

Introducing High-Throughput Proteomics in India – Webinar

Measure 11,000 proteins from 50ul serum / blood

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